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Esketamine nasal spray 28mg, sold under the brand name SPRAVATO, is a prescription medicine used with an oral antidepressant to treat adults with treatment-resistant depression or major depressive disorder with acute suicidal thoughts.
What It Treats
- Treatment-Resistant Depression (TRD): Used when at least two standard oral antidepressants have failed to work.
- Major Depressive Disorder (MDD): Used for acute suicidal ideation or behavior.
How It Works
- Glutamate Target: It targets glutamate, the main chemical messenger in the brain for excitement, unlike older drugs that target serotonin.
- Fast Relief: It can reduce depressive symptoms within hours or days instead of weeks.
How It Is Give
- Supervised Setting: You must self-administer the spray at a certified medical clinic under a SPRAVATO REMS Program.
- Monitoring: Staff monitor you for at least two hours after your dose. You cannot drive until the next day after a full sleep.
- Preparation: Do not eat for two hours or drink liquids for 30 minutes before using the spray
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